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Article

Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore.

Proceedings of the National Academy of Sciences of the United States of America - 11 Mar 2014

Zhang Zhifen, Park Minyoung, Tam John, Auger Anick, Beilhartz Greg L, Lacy D Borden, Melnyk Roman A

Abstract excerpt

Disease associated with Clostridium difficile infection is caused by the actions of the homologous toxins TcdA and TcdB on colonic epithelial cells. Binding to target cells triggers toxin internalization into acidified vesicles, whereupon cryptic segments from within the 1,050-aa translocation domain unfurl and insert into the bounding membrane, creating a transmembrane passageway to the cytosol. Our current...

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Identifiers

PMID: 24567384
DOI: 10.1073/pnas.1400680111
PMCID: PMC3956163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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