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Article

The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition.

Scientific reports - 9 May 2018

Ruiz-Carrillo David, Lin Jianqing, El Sahili Abbas, Wei Meng, Sze Siu Kwan, Cheung Peter C F, Doerig Christian, Lescar Julien

Abstract excerpt

Malaria causes every year over half-a-million deaths. The emergence of parasites resistant to available treatments makes the identification of new targets and their inhibitors an urgent task for the development of novel anti-malaria drugs. Protein kinase CK2 is an evolutionary-conserved eukaryotic serine/threonine protein kinase that in Plasmodium falciparum (PfCK2) has been characterized as a promising target...

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Share to Casein Kinase II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

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Source

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Identifiers

PMID: 29743645
DOI: 10.1038/s41598-018-25738-5
PMCID: PMC5943518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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