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Article

Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.

Chemistry & biology - 1 Nov 2005

Battistutta Roberto, Mazzorana Marco, Sarno Stefania, Kazimierczuk Zygmunt, Zanotti Giuseppe, Pinna Lorenzo A

Abstract excerpt

CK2 is a very pleiotropic protein kinase whose high constitutive activity is suspected to cooperate to neoplasia. Here, the crystal structure of the complexes between CK2 and three selective tetrabromo-benzimidazole derivatives inhibiting CK2 with Ki values between 40 and 400 nM are presented. The ligands bind to the CK2 active site in a different way with respect to the parent compound TBB. They enter more...

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Source

Identifiers

PMID: 16298300
DOI: 10.1016/j.chembiol.2005.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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