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The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis

12 Mar 2021

Abstract excerpt

Casein kinase 2 (CK2) is a pleiotropic kinase phosphorylating substrates in different cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum, PfCK2 is vital for asexual proliferation of blood-stage parasites. Here, we applied CRISPR/Cas9-based gene editing to investigate the function of the PfCK2α catalytic subunit in gametocytes, the sexual forms of the parasite that are essential for...

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PMID: 33712726
DOI: 10.1038/s42003-021-01873-0

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