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Article

HIV-1 tat expression and sulphamethoxazole hydroxylamine mediated oxidative stress alter the disulfide proteome in Jurkat T cells.

Virology journal - 9 May 2018

Adeyanju Kemi, Bend John R, Rieder Michael J, Dekaban Gregory A

Abstract excerpt

BACKGROUND: Adverse drug reactions (ADRs) are a significant problem for HIV patients, with the risk of developing ADRs increasing as the infection progresses to AIDS. However, the pathophysiology underlying ADRs remains unknown. Sulphamethoxazole (SMX) via its active metabolite SMX-hydroxlyamine, when used prophylactically for pneumocystis pneumonia in HIV-positive individuals, is responsible for a high incidence...

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Share to Disulfides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to tat Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 29743079
DOI: 10.1186/s12985-018-0991-x
PMCID: PMC5944096

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