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Article

Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 2002

Seibert Christoph, Cadene Martine, Sanfiz Anthony, Chait Brian T, Sakmar Thomas P

Abstract excerpt

The CC-chemokine receptor 5 (CCR5) is the major coreceptor for the entry of macrophage-tropic (R5) HIV-1 strains into target cells. Posttranslational sulfation of tyrosine residues in the N-terminal tail of CCR5 is critical for high affinity interaction of the receptor with the HIV-1 envelope glycoprotein gp120 in complex with CD4. Here, we focused on defining precisely the sulfation pattern of the N terminus of...

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Share to Chromatography, High Pressure Liquid
Share to Peptide Fragments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Processing, Post-Translational

Share to Receptors, CCR5

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Share to Sulfotransferases

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Source

Open in PubMed Open full text

Identifiers

PMID: 12169668
DOI: 10.1073/pnas.172380899
PMCID: PMC123205

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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