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The cytosolic tryparedoxin peroxidase from Trypanosoma cruzi induces a pro-inflammatory Th1 immune response in a peroxidatic cysteine-dependent manner.

Immunology - 1 May 2021

López Lucía, Chiribao María Laura, Girard Magalí C, Gómez Karina A, Carasi Paula, Fernandez Marisa, Hernandez Yolanda, Robello Carlos, Freire Teresa, Piñeyro María Dolores

Abstract excerpt

Trypanosoma cruzi cytosolic tryparedoxin peroxidase (c-TXNPx) is a 2-Cys peroxiredoxin (Prx) with an important role in detoxifying host cell oxidative molecules during parasite infection. c-TXNPx is a virulence factor, as its overexpression enhances parasite infectivity and resistance to exogenous oxidation. As Prxs from other organisms possess immunomodulatory properties, we studied the effects of c-TXNPx in the...

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PMID: 33410127
DOI: 10.1111/imm.13302
PMCID: PMC8044337

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