Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS.

Pharmacogenetics - 1 Dec 2000

Wolkenstein P, Loriot M A, Aractingi S, Cabelguenne A, Beaune P, Chosidow O

Abstract excerpt

The use of sulphonamides is complicated by a high rate of cutaneous reactions in AIDS. Metabolic risk factors have been suspected for these reactions. We conducted a prospective study to evaluate whether glutathione S-transferase M1 null genotype, glutathione deficiency and acetylator status as risk factors. To explain the high frequency of slow acetylator phenotype in AIDS patients, we compared...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acquired Immunodeficiency Syndrome
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Caffeine

Share to Evaluation Studies as Topic

Share to Inactivation, Metabolic

Share to Pneumonia, Pneumocystis

Share to Sulfonamides

Share to Toxoplasmosis

Source

Identifiers

PMID: 11191886
DOI: 10.1097/00008571-200012000-00007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS.PMID 11191886Read ↗

A slow acetylator genotype is a risk factor for sulphonamide-induced toxic epidermal necrolysis and Stevens-Johnson syndrome.Semantic proximity Read ↗

Acetylation phenotype and cutaneous hypersensitivity to trimethoprim-sulphamethoxazole in HIV-infected patients.Semantic proximity Read ↗

Relationship between high incidence of adverse dapsone reactions and slow acetylate phenotype or low plasma/lymphocyte glutathione level.Semantic proximity Read ↗

Influence of polymorphic N-acetyltransferases on non-malignant spontaneous disorders and on response to drugs.Semantic proximity Read ↗

Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity reactions.Semantic proximity Read ↗

Acetylator phenotype prevalence in HIV-infected patients without previous trimethoprim-sulfamethoxazole hypersensitivity.Semantic proximity Read ↗

Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.Semantic proximity Read ↗

Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis.Semantic proximity Read ↗

N-acetyltransferase 2 polymorphism in patients infected with human immunodeficiency virus.Semantic proximity Read ↗

Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity.Semantic proximity Read ↗

Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.Semantic proximity Read ↗

Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.