Article
Redox potential of human thioredoxin 1 and identification of a second dithiol/disulfide motif.
The Journal of biological chemistry - 29 Aug 2003
Watson Walter H, Pohl Jan, Montfort William R, Stuchlik Olga, Reed Matthew S, Powis Garth, Jones Dean P
Abstract excerpt
Thioredoxin (Trx1) is a redox-active protein containing two active site cysteines (Cys-32 and Cys-35) that cycle between the dithiol and disulfide forms as Trx1 reduces target proteins. Examination of the redox characteristics of this active site dithiol/disulfide couple is complicated by the presence of three additional non-active site cysteines. Using the redox Western blot technique and matrix assisted laser...
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