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Activin receptors in human cancer: Functions, mechanisms, and potential clinical applications

16 Feb 2024

Abstract excerpt

Activins are members of the transforming growth factor-β (TGF-β) superfamily and act as key regulators in various physiological processes, such as follicle and embryonic development, as well as in multiple human diseases, including cancer. They have been established to signal through three type I and two type II serine/threonine kinase receptors, which, upon ligand binding, form a final signal-transducing...

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PMID: 38369212
DOI: 10.1016/j.bcp.2024.116061

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