Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ciliary margin-derived BMP4 does not have a major role in ocular development.

PloS one - 1 Jan 2018

Rausch Rebecca L, Libby Richard T, Kiernan Amy E

Abstract excerpt

Heterozygous Bmp4 mutations in humans and mice cause severe ocular anterior segment dysgenesis (ASD). Abnormalities include pupil displacement, corneal opacity, iridocorneal adhesions, and variable intraocular pressure, as well as some retinal and vascular defects. It is presently not known what source of BMP4 is responsible for these defects, as BMP4 is expressed in several developing ocular and surrounding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anterior Eye Segment
Share to Bone Morphogenetic Protein 4
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Intraocular Pressure

Share to Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 29738572
DOI: 10.1371/journal.pone.0197048
PMCID: PMC5940228

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ciliary margin-derived BMP4 does not have a major role in ocular development.PMID 29738572Read ↗

Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure.Semantic proximity Read ↗

Inactivation of Smad4 leads to impaired ocular development and cataract formation.Semantic proximity Read ↗

Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-β signaling system in the embryonic mouse retina.Semantic proximity Read ↗

Bmp4 from the optic vesicle specifies murine retina formation.Semantic proximity Read ↗

The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness.Semantic proximity Read ↗

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fateSemantic proximity Read ↗

Conditional deletion of AP-2β in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma.Semantic proximity Read ↗

Loss of Axin2 Causes Ocular Defects During Mouse Eye Development.Semantic proximity Read ↗

Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies.Semantic proximity Read ↗

Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eyeSemantic proximity Read ↗

Loss of maternal Smad5 in zebrafish embryos affects patterning and morphogenesis of optic primordia.Semantic proximity Read ↗

Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.