Article
Inactivation of Smad4 leads to impaired ocular development and cataract formation.
Biochemical and biophysical research communications - 1 Oct 2010
Liu Ying, Kawai Kirio, Khashabi Shabnam, Deng Chuxia, Liu Yi-Hsin, Yiu Samuel
Abstract excerpt
PURPOSE: Signaling by members of the TGFβ superfamily of molecules is essential for embryonic development and homeostasis. Smad4, a key intracellular mediator in TGFβ signaling, forms transcriptional activator complexes with Activin-, BMP-, and TGFβ-restricted Smad proteins. However, the functional role of Smad4 in controlling different visual system compartments has not been fully investigated. METHODS: Using...
Topics
- Actins
- Animals
- Apoptosis
- Cataract
- Cell Proliferation
- Eye Abnormalities
- Eyelids
- Lens, Crystalline
- Mice
- Mice, Transgenic
- Mutation
- Smad4 Protein