Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivation of Smad4 leads to impaired ocular development and cataract formation.

Biochemical and biophysical research communications - 1 Oct 2010

Liu Ying, Kawai Kirio, Khashabi Shabnam, Deng Chuxia, Liu Yi-Hsin, Yiu Samuel

Abstract excerpt

PURPOSE: Signaling by members of the TGFβ superfamily of molecules is essential for embryonic development and homeostasis. Smad4, a key intracellular mediator in TGFβ signaling, forms transcriptional activator complexes with Activin-, BMP-, and TGFβ-restricted Smad proteins. However, the functional role of Smad4 in controlling different visual system compartments has not been fully investigated. METHODS: Using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Apoptosis
Share to Cataract

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Eye Abnormalities

Share to Eyelids

Share to Lens, Crystalline

Share to Smad4 Protein

Source

Identifiers

PMID: 20735985
DOI: 10.1016/j.bbrc.2010.08.065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of Smad4 leads to impaired ocular development and cataract formation.PMID 20735985Read ↗

Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-β signaling system in the embryonic mouse retina.Semantic proximity Read ↗

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fateSemantic proximity Read ↗

A mouse model of aniridia reveals the in vivo downstream targets of Pax6 driving iris and ciliary body development in the eye.Semantic proximity Read ↗

TGF-β/Smad Signalling Activation by HTRA1 Regulates the Function of Human Lens Epithelial Cells and Its Mechanism in Posterior Subcapsular Congenital CataractSemantic proximity Read ↗

TGFβ Receptor Expression in Lens: Implications for Differentiation and CataractogenesisSemantic proximity Read ↗

Ciliary margin-derived BMP4 does not have a major role in ocular development.Semantic proximity Read ↗

Eyelid closure in embryogenesis is required for ocular adnexa development.Semantic proximity Read ↗

Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in miceSemantic proximity Read ↗

Smad signalling in the ovarySemantic proximity Read ↗

Reduced expression of Pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucomaSemantic proximity Read ↗

Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation.Semantic proximity Read ↗

Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.