Article
Conditional deletion of AP-2β in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma.
Disease models & mechanisms - 1 Aug 2016
Martino Vanessa B, Sabljic Thomas, Deschamps Paula, Green Rebecca M, Akula Monica, Peacock Erica, Ball Alexander, Williams Trevor, West-Mays Judith A
Abstract excerpt
Anterior segment dysgenesis (ASD) encompasses a group of developmental disorders in which a closed angle phenotype in the anterior chamber of the eye can occur and 50% of patients develop glaucoma. Many ASDs are thought to involve an inappropriate patterning and migration of the periocular mesenchyme (POM), which is derived from cranial neural crest cells (NCCs) and mesoderm. Although, the mechanism of this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.