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Article

Loss of maternal Smad5 in zebrafish embryos affects patterning and morphogenesis of optic primordia.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2003

Hammerschmidt Matthias, Kramer Carina, Nowak Matthias, Herzog Wiebke, Wittbrodt Joachim

Abstract excerpt

The mechanisms of patterning and morphogenesis of vertebrate eye primordia are heavily debated. Taking advantage of the maternal effect of a zebrafish smad5 null mutation (Mm169), we investigate the effect of early signaling by members of the bone morphogenetic proteins (Bmps) on eye field patterning and optic vesicle morphogenesis. In contrast to previous Xenopus and chick studies demonstrating a late...

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Identifiers

PMID: 12701105
DOI: 10.1002/dvdy.10281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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