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The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness.

Mechanisms of development - 1 Apr 2010

Schonthaler Helia B, Franz-Odendaal Tamara A, Hodel Corinne, Gehring Ines, Geisler Robert, Schwarz Heinz, Neuhauss Stephan C F, Dahm Ralf

Abstract excerpt

The development of the eye lens is one of the classical paradigms of induction during embryonic development in vertebrates. But while there have been numerous studies aimed at discovering the genetic networks controlling early lens development, comparatively little is known about later stages, including the differentiation of secondary lens fibre cells. The analysis of mutant zebrafish isolated in forward genetic...

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PMID: 20117205
DOI: 10.1016/j.mod.2010.01.005

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