Article
Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure.
BMC genetics - 1 Jan 2001
Chang B, Smith R S, Peters M, Savinova O V, Hawes N L, Zabaleta A, Nusinowitz S, Martin J E, Davisson M L, Cepko C L, Hogan B L, John S W
Abstract excerpt
BACKGROUND: Glaucoma is a blinding disease usually associated with high intraocular pressure (IOP). In some families, abnormal anterior segment development contributes to glaucoma. The genes causing anterior segment dysgenesis and glaucoma in most of these families are not identified and the affected developmental processes are poorly understood. Bone morphogenetic proteins (BMPs) participate in various...
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