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Article

Phase variation of Clostridium difficile virulence factors

14 Aug 2017

Abstract excerpt

Clostridium difficile is a leading cause of nosocomial infections, causing disease that ranges from mild diarrhea to potentially fatal colitis. A variety of surface proteins, including flagella, enable C. difficile colonization of the intestine. Once in the intestine, toxigenic C. difficile secretes two glucosylating toxins, TcdA and TcdB, which elicit inflammation and diarrheal disease symptoms. Regulation of...

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PMID: 28806147
DOI: 10.1080/19490976.2017.1362526

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