Targeting ARID1A mutations in cancer.

Abstract excerpt

Genes encoding SWI/SNF chromatin remodeling complex subunits are collectively mutated in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein product binds DNA. ARID1A gene alterations result in loss of function. It is the most commonly mutated member of the SWI/SNF complex, being aberrant in ∼6% of cancers overall, including ovarian clear cell cancers (∼45% of patients) and uterine...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA-Binding Proteins
• Share to Enzyme Inhibitors
• Share to Immune Checkpoint Inhibitors