Article
ARID1B is a specific vulnerability in ARID1A-mutant cancers.
Nature medicine - 1 Mar 2014
Helming Katherine C, Wang Xiaofeng, Wilson Boris G, Vazquez Francisca, Haswell Jeffrey R, Manchester Haley E, Kim Youngha, Kryukov Gregory V, Ghandi Mahmoud, Aguirre Andrew J, Jagani Zainab, Wang Zhong, Garraway Levi A, Hahn William C, Roberts Charles W M
Abstract excerpt
Recent studies have revealed that ARID1A, encoding AT-rich interactive domain 1A (SWI-like), is frequently mutated across a variety of human cancers and also has bona fide tumor suppressor properties. Consequently, identification of vulnerabilities conferred by ARID1A mutation would have major relevance for human cancer. Here, using a broad screening approach, we identify ARID1B, an ARID1A homolog whose gene...
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