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Article

Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage.

Journal of thrombosis and haemostasis : JTH - 1 Jul 2018

Wan H, Wang Y, Ai J, Brathwaite S, Ni H, Macdonald R L, Hol E M, Meijers J C M, Vergouwen M D I

Abstract excerpt

Essentials von Willebrand Factor (VWF) and ADAMTS13 may affect early injury after subarachnoid hemorrhage (SAH). Early brain injury was assessed in VWF-/- , ADAMTS13-/- and recombinant (r) ADAMTS13 treated mice. VWF-/- and rADAMTS13 treated mice had less brain injury than ADAMTS13-/- and wild-type mice. Early administration of rADAMTS13 may improve outcome after SAH by reducing early brain injury. SUMMARY:...

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Identifiers

PMID: 29729651
DOI: 10.1111/jth.14136
PMCID: PMC6055612

Genes

VWF
ADAMTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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