Article
Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016
Dhanesha Nirav, Prakash Prem, Doddapattar Prakash, Khanna Ira, Pollpeter Molly J, Nayak Manasa K, Staber Janice M, Chauhan Anil K
Abstract excerpt
OBJECTIVE: von Willebrand factor (VWF), which is synthesized in endothelial cells and megakaryocytes, is known to worsen stroke outcome. In vitro studies suggest that platelet-derived VWF (Plt-VWF) is biochemically different from the endothelial cell-derived VWF (EC-VWF). However, little is known about relative contribution of different pools of VWF in stroke. APPROACH AND RESULTS: Using bone marrow...
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