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Article

ABCC2 rs2273697 is associated with valproic acid concentrations in patients with epilepsy on valproic acid monotherapy.

Die Pharmazie - 1 May 2018

Chen Juan, Su Qi-Biao, Tao Yu-Qian, Qin Jia-Ming, Zhou Yi, Zhou Shan, Li Hong-Liang, Chen Zhuo-Jia, Zhou Ya-Fang, Zhou Lie-Min, Wang Xue-Ding, Huang Min

Abstract excerpt

Valproic acid (VPA), a widely used antiepileptic drug, is characterized by intensive inter-individual variability in concentration. Both efflux and influx transporters are reported to play important roles in the disposition of VPA, however, no comprehensive investigation into the association of the single nucleotide polymorphism (SNP) in ABC/SLC families with VPA concentration are reported. In the present study,...

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Source

Identifiers

PMID: 29724294
DOI: 10.1691/ph.2018.7344

Genes

ABCC2
ABCC4
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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