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Article

Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.

BioMed research international - 1 Jan 2020

Lu Yuan, Su Quanping, Li Ming, Dayimu Alimu, Dai Xiaoyu, Wang Zhiheng, Che Fengyuan, Xue Fuzhong

Abstract excerpt

PURPOSE: The efficacy of valproic acid (VPA) varies widely in clinical treatment of epileptic patients. Our study is aimed at exploring a potential association between polymorphisms of SCN1A, SCN2A, and UGT2B7 genetic factors and VPA responses. METHODS: In this observational study, a total of 114 epileptic patients only treated with VPA for at least 1 year were included to explore the genetic polymorphisms of...

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Identifiers

PMID: 32185219
DOI: 10.1155/2020/8096235
PMCID: PMC7063186

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