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Article

Effect of SCN1Aand SCN2A gene polymorphisms on the efficacy of valproic acid treatment in Chinese children with epilepsy.

PloS one - 1 Jan 2024

Bao Zejun, Li Huanzhou, Hu Jing, Zhao Ru, Yan Ling, Zheng Aibin

Abstract excerpt

OBJECTIVE: Epilepsy patients exhibit considerable differences in their response to sodium valproate (VPA) therapy, a phenomenon that might be attributed to individual genetic variances. The role of genetic variations, specifically in sodium channels encoded by SCN1A and SCN2A genes, in influencing the effectiveness of VPA in treating epilepsy is still debated. This research focuses on examining the impact of...

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Source

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Identifiers

PMID: 38837984
DOI: 10.1371/journal.pone.0304869
PMCID: PMC11152251

Genes

SCN2A
SCN1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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