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Article

Matching Protein Interfaces for Improved Medium-Chain Fatty Acid Production.

ACS synthetic biology - 18 May 2018

Sarria Stephen, Bartholow Thomas G, Verga Adam, Burkart Michael D, Peralta-Yahya Pamela

Abstract excerpt

Medium-chain fatty acids (MCFAs) are key intermediates in the synthesis of medium-chain chemicals including α-olefins and dicarboxylic acids. In bacteria, microbial production of MCFAs is limited by the activity and product profile of fatty acyl-ACP thioesterases. Here, we engineer a heterologous bacterial medium-chain fatty acyl-ACP thioesterase for improved MCFA production in Escherichia coli. Electrostatically...

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Identifiers

PMID: 29722970
DOI: 10.1021/acssynbio.7b00334
PMCID: PMC6296256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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