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Article

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria.

The EMBO journal - 6 Sept 2006

Schujman Gustavo E, Guerin Marcelo, Buschiazzo Alejandro, Schaeffer Francis, Llarrull Leticia I, Reh Georgina, Vila Alejandro J, Alzari Pedro M, de Mendoza Diego

Abstract excerpt

Malonyl-CoA is an essential intermediate in fatty acid synthesis in all living cells. Here we demonstrate a new role for this molecule as a global regulator of lipid homeostasis in Gram-positive bacteria. Using in vitro transcription and binding studies, we demonstrate that malonyl-CoA is a direct and specific inducer of Bacillus subtilis FapR, a conserved transcriptional repressor that regulates the expression...

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Identifiers

PMID: 16932747
DOI: 10.1038/sj.emboj.7601284
PMCID: PMC1560364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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