Article
Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction.
The Journal of biological chemistry - 26 Dec 2003
Zhang Yong-Mei, Wu Bainan, Zheng Jie, Rock Charles O
Abstract excerpt
Fatty acid synthesis in bacteria is catalyzed by a set of individual enzymes collectively known as type II fatty-acid synthase. Each enzyme interacts with acyl carrier protein (ACP), which shuttles the pathway intermediates between the proteins. The type II enzymes do not possess primary sequence similarity that defines a common ACP-binding site, but rather are hypothesized to possess an...
Topics
- Acyl Carrier Protein
- Alcohol Oxidoreductases
- Amino Acid Sequence
- Arginine
- Binding Sites
- Binding, Competitive
- Dose-Response Relationship, Drug
- Escherichia coli
- Isoleucine
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis
- Mutation