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Article

Engineering fungal de novo fatty acid synthesis for short chain fatty acid production.

Nature communications - 10 Mar 2017

Gajewski Jan, Pavlovic Renata, Fischer Manuel, Boles Eckhard, Grininger Martin

Abstract excerpt

Fatty acids (FAs) are considered strategically important platform compounds that can be accessed by sustainable microbial approaches. Here we report the reprogramming of chain-length control of Saccharomyces cerevisiae fatty acid synthase (FAS). Aiming for short-chain FAs (SCFAs) producing baker's yeast, we perform a highly rational and minimally invasive protein engineering approach that leaves the molecular...

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Identifiers

PMID: 28281527
DOI: 10.1038/ncomms14650
PMCID: PMC5353594

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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