Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combined VEGF/PDGF inhibition using axitinib induces αSMA expression and a pro-fibrotic phenotype in human pericytes.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Jun 2018

Siedlecki Jakob, Asani Ben, Wertheimer Christian, Hillenmayer Anna, Ohlmann Andreas, Priglinger Claudia, Priglinger Siegfried, Wolf Armin, Eibl-Lindner Kirsten

Abstract excerpt

PURPOSE: Large trials on anti-VEGF/PDGF (vascular endothelial/platelet-derived growth factor) combination therapy have been established to improve management of neovascular activity in age-related macular degeneration. Targeting pericytes, PDGF is thought to induce vessel regression and reduce fibrovascular scarring. The fate of pericytes exposed to anti-VEGF/PDGF combination therapy is not clear. Therefore, this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoskeletal Proteins
Share to Macular Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Proteins

Share to Pericytes

Share to Platelet-Derived Growth Factor

Share to Real-Time Polymerase Chain Reaction

Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 29721663
DOI: 10.1007/s00417-018-3987-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined VEGF/PDGF inhibition using axitinib induces αSMA expression and a pro-fibrotic phenotype in human pericytes.PMID 29721663Read ↗

Angiopoietin-2 and vascular endothelial growth factor α inhibition by faricimab reduces pericyte-to-myofibroblast transition and the myofibroblast phenotype in vitro.Semantic proximity Read ↗

In vivo angiogenic phenotype of endothelial cells and pericytes induced by vascular endothelial growth factor-A.Semantic proximity Read ↗

The PDGF/PDGFR pathway as a drug target.Semantic proximity Read ↗

Spontaneous fibroblast‐derived pericyte recruitment in a human tissue‐engineered angiogenesis model in vitroSemantic proximity Read ↗

Phenotypical differences in connective tissue cells emerging from microvascular pericytes in response to overexpression of PDGF-B and TGF-β1 in normal skin in vivo.Semantic proximity Read ↗

PKCβII/HuR/VEGF: A new molecular cascade in retinal pericytes for the regulation of VEGF gene expressionSemantic proximity Read ↗

Effects of the histone deacetylase inhibitor valproic acid on human pericytes in vitro.Semantic proximity Read ↗

Platelet‑derived growth factor‑BB promotes proliferation and migration of retinal microvascular pericytes by up‑regulating the expression of C‑X‑C chemokine receptor types 4Semantic proximity Read ↗

Predominant control of PDGF/PDGF receptor signaling in the migration and proliferation of human adipose‑derived stem cells under culture conditions with a combination of growth factorsSemantic proximity Read ↗

Alpha5 and alpha2 integrin gene transfers mimic the PDGF-B-induced transformed phenotype of fibroblasts in human skin.Semantic proximity Read ↗

Engineered microenvironments for synergistic VEGF - Integrin signalling during vascularization.Semantic proximity Read ↗

Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.