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Article

Engineered microenvironments for synergistic VEGF - Integrin signalling during vascularization.

Biomaterials - 1 May 2017

Moulisová Vladimíra, Gonzalez-García Cristina, Cantini Marco, Rodrigo-Navarro Aleixandre, Weaver Jessica, Costell Mercedes, Sabater I Serra Roser, Dalby Matthew J, García Andrés J, Salmerón-Sánchez Manuel

Abstract excerpt

We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous organization of fibronectin (FN) into nanonetworks which provide availability of critical binding domains. Importantly, the growth factor binding (FNIII12-14) and integrin binding (FNIII9-10) regions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28279265
DOI: 10.1016/j.biomaterials.2017.02.024
PMCID: PMC5354119

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