Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypical differences in connective tissue cells emerging from microvascular pericytes in response to overexpression of PDGF-B and TGF-β1 in normal skin in vivo.

The American journal of pathology - 1 Jun 2013

Rodriguez Alejandro, Friman Tomas, Kowanetz Marcin, van Wieringen Tijs, Gustafsson Renata, Sundberg Christian

Abstract excerpt

Fibrosis is a deleterious consequence of chronic inflammation in a number of human pathologies ultimately leading to organ dysfunction and failure. Two growth factors that are important in blood vessel physiology and tissue fibrosis, platelet-derived growth factor (PDGF)-B and transforming growth factor (TGF)-β1, were investigated. Adenoviral vectors were used to induce transient overexpression of these growth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microvessels

Share to Neovascularization, Physiologic

Share to Pericytes

Share to Proteoglycans

Share to Proto-Oncogene Proteins c-sis

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 23570836
DOI: 10.1016/j.ajpath.2013.01.054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypical differences in connective tissue cells emerging from microvascular pericytes in response to overexpression of PDGF-B and TGF-β1 in normal skin in vivo.PMID 23570836Read ↗

Genetically Modified Human Epidermis Overexpressing PDGF-A Directs the Development of a Cellular and Vascular Connective Tissue Stroma When Transplanted to Athymic Mice–Implications for the Use of Genetically Modified Keratinocytes to Modulate Dermal RegenerationSemantic proximity Read ↗

Understanding the origin, activation and regulation of matrix‐producing myofibroblasts for treatment of fibrotic diseaseSemantic proximity Read ↗

Origins of fibrosis: pericytes take centre stageSemantic proximity Read ↗

Alpha5 and alpha2 integrin gene transfers mimic the PDGF-B-induced transformed phenotype of fibroblasts in human skin.Semantic proximity Read ↗

Spontaneous fibroblast‐derived pericyte recruitment in a human tissue‐engineered angiogenesis model in vitroSemantic proximity Read ↗

Signaling Role of Pericytes in Vascular Health and Tissue HomeostasisSemantic proximity Read ↗

TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic DiseasesSemantic proximity Read ↗

Sequential Inflammatory and Matrisome Programs Drive Remodeling of the Mouse Carotid-Jugular Arteriovenous FistulaSemantic proximity Read ↗

A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease.Semantic proximity Read ↗

Phenotypic changes and possible angiogenic roles of pericytes during wound healing in the mouse skin.Semantic proximity Read ↗

Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis.Semantic proximity Read ↗

β-III tubulin identifies anti-fibrotic state of pericytes in pulmonary fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.