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Article

Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2006

Chen Cheng-Nan, Li Yi-Shuan J, Yeh Yi-Ting, Lee Pei-Ling, Usami Shunichi, Chien Shu, Chiu Jeng-Jiann

Abstract excerpt

The phenotype of smooth muscle cells (SMCs) plays an important role in vascular function in health and disease. We investigated the mechanism of modulation of SMC phenotype (from contractile to synthetic) induced by the synergistic action of a growth factor (platelet-derived growth factor, PDGF-BB) and a cytokine (interleukin, IL-1beta). Human aortic SMCs grown on polymerized collagen showed high expression...

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Identifiers

PMID: 16477012
DOI: 10.1073/pnas.0510973103
PMCID: PMC1413813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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