Article
De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.
Nature communications - 2 May 2018
Hyrenius-Wittsten Axel, Pilheden Mattias, Sturesson Helena, Hansson Jenny, Walsh Michael P, Song Guangchun, Kazi Julhash U, Liu Jian, Ramakrishan Ramprasad, Garcia-Ruiz Cristian, Nance Stephanie, Gupta Pankaj, Zhang Jinghui, Rönnstrand Lars, Hultquist Anne, Downing James R, Lindkvist-Petersson Karin, Paulsson Kajsa, Järås Marcus, Gruber Tanja A, Ma Jing, Hagström-Andersson Anna K
Abstract excerpt
Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate that FLT3 ITD , FLT3 N676K , and NRAS G12D accelerate KMT2A-MLLT3 leukemia onset. Further, also subclonal FLT3 N676K mutations accelerate disease,...
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