Article
Molecular pathogenesis of disease progression in MLL-rearranged AML.
Leukemia - 1 Mar 2019
Kotani Shinichi, Yoda Akinori, Kon Ayana, Kataoka Keisuke, Ochi Yotaro, Shiozawa Yusuke, Hirsch Cassandra, Takeda June, Ueno Hiroo, Yoshizato Tetsuichi, Yoshida Kenichi, Nakagawa Masahiro M, Nannya Yasuhito, Kakiuchi Nobuyuki, Yamauchi Takuji, Aoki Kosuke, Shiraishi Yuichi, Miyano Satoru, Maeda Takahiro, Maciejewski Jaroslaw P, Takaori-Kondo Akifumi, Ogawa Seishi, Makishima Hideki
Abstract excerpt
Leukemic relapse is frequently accompanied by progressively aggressive clinical course. To understand the molecular mechanism of leukemic relapse, MLL/AF9-transformed mouse leukemia cells were serially transplanted in C57BL/6 mice (N = 96) by mimicking repeated recurrences, where mutations were monitored by exome sequencing (N = 42). The onset of leukemia was progressively promoted with advanced transplants,...
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