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Article

Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.

Leukemia - 1 Apr 2023

Straube Jasmin, Eifert Theresa, Vu Therese, Janardhanan Yashaswini, Haldar Rohit, von Eyss Björn, Cooper Leanne, Bruedigam Claudia, Ling Victoria Y, Cooper Emily, Patch Ann-Marie, Bullinger Lars, Schnoeder Tina M, Bywater Megan, Heidel Florian H, Lane Steven W

Abstract excerpt

Murine models offer a valuable tool to recapitulate genetically defined subtypes of AML, and to assess the potential of compound mutations and clonal evolution during disease progression. This is of particular importance for difficult to treat leukemias such as FLT3 internal tandem duplication (ITD) positive AML. While conditional gene targeting by Cre recombinase is a powerful technology that has revolutionized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36739348
DOI: 10.1038/s41375-023-01832-0
PMCID: PMC10079527

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