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Article

Simultaneous Single Cell Gene Expression and EGFR Mutation Analysis of Circulating Tumor Cells Reveals Distinct Phenotypes in NSCLC.

Advanced biosystems - 1 Aug 2020

Owen Sarah, Lo Ting-Wen, Fouladdel Shamileh, Zeinali Mina, Keller Evan, Azizi Ebrahim, Ramnath Nithya, Nagrath Sunitha

Abstract excerpt

While cancer cell populations are known to be highly heterogeneous within a tumor, the current gold standard of tumor profiling is through a tumor biopsy. These biopsies are invasive and prone to missing these clones due to spatial heterogeneity, and this bulk analysis approach can miss information from rare subpopulations. To noninvasively investigate tumor cell heterogeneity, a streamlined workflow is developed...

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Identifiers

PMID: 32700450
DOI: 10.1002/adbi.202000110
PMCID: PMC7883301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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