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Article

Telomerase-Independent Paths to Immortality in Predictable Cancer Subtypes

1 Jan 2012

Abstract excerpt

The vast majority of cancers commandeer the activity of telomerase - the remarkable enzyme responsible for prolonging cellular lifespan by maintaining the length of telomeres at the ends of chromosomes. Telomerase is only normally active in embryonic and highly proliferative somatic cells. Thus, targeting telomerase is an attractive anti-cancer therapeutic rationale currently under investigation in various phases...

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PMID: 22315652
DOI: 10.7150/jca.3965

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