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Article

Daptomycin selects for genetic and phenotypic adaptations leading to antibiotic tolerance in MRSA.

The Journal of antimicrobial chemotherapy - 1 Aug 2018

Berti Andrew D, Shukla Neehal, Rottier Aaron D, McCrone J Sue, Turner Hannah M, Monk Ian R, Baines Sarah L, Howden Benjamin P, Proctor Richard A, Rose Warren E

Abstract excerpt

Objectives: Daptomycin non-susceptibility in Staphylococcus aureus can emerge via the accumulation of single or multiple mutations, each resulting in a slight increase in the daptomycin MIC. The daptomycin-non-susceptible phenotype may include other features such as daptomycin tolerance. This study identifies S. aureus genomic regions that frequently develop mutations following prolonged daptomycin exposure but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29718242
DOI: 10.1093/jac/dky148
PMCID: PMC6054297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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