Article
Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in Staphylococcus aureus.
mBio - 8 Dec 2020
Giulieri Stefano G, Guérillot Romain, Kwong Jason C, Monk Ian R, Hayes Ashleigh S, Daniel Diane, Baines Sarah, Sherry Norelle L, Holmes Natasha E, Ward Peter, Gao Wei, Seemann Torsten, Stinear Timothy P, Howden Benjamin P
Abstract excerpt
Antistaphylococcal penicillins such as oxacillin are the key antibiotics in the treatment of invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections; however, mec gene-independent resistance adaptation can cause treatment failure. Despite its clinical relevance, the basis of this phenomenon remains poorly understood. Here, we investigated the genomic adaptation to oxacillin at an unprecedented...
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