Article
Using Droplet Digital PCR to Analyze Allele-Specific RNA Expression.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Kamitaki Nolan, Usher Christina L, McCarroll Steven A
Abstract excerpt
Genome-wide association studies have discovered thousands of common alleles that associate with human phenotypes and disease. Many of these variants are in non-protein-coding (regulatory) regions and are believed to affect phenotypes by modifying gene expression. In any organism with a diploid genome, such as humans, measuring the expression of each allele of a gene provides a well-controlled way to identify...
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