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Article

Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human.

Nature methods - 1 Aug 2009

Zhang Kun, Li Jin Billy, Gao Yuan, Egli Dieter, Xie Bin, Deng Jie, Li Zhe, Lee Je-Hyuk, Aach John, Leproust Emily M, Eggan Kevin, Church George M

Abstract excerpt

We developed a digital RNA allelotyping method for quantitatively interrogating allele-specific gene expression. This method involves ultra-deep sequencing of padlock-captured single-nucleotide polymorphisms (SNPs) from the transcriptome. We characterized four cell lines established from two human subjects in the Personal Genome Project. Approximately 11-22% of the heterozygous mRNA-associated SNPs showed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19620972
DOI: 10.1038/nmeth.1357
PMCID: PMC2742772

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