Article
Copy Number Variation Analysis by Droplet Digital PCR.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Härmälä Suvi K, Butcher Robert, Roberts Chrissy H
Abstract excerpt
The health impact of many copy number variants in our genome remains still largely to be discovered. Detecting and genotyping this often complex variation presents a technical challenge. Here we describe a 96-well format droplet digital PCR (ddPCR) protocol for genotyping a common copy variant in the human haptoglobin gene. ddPCR allows for high-throughput and accurate quantitation of gene copy numbers.
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