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Regulation of the Cell Cycle by ncRNAs Affects the Efficiency of CDK4/6 Inhibition

18 May 2023

Abstract excerpt

Cyclin-dependent kinases (CDKs) regulate cell division at multiple levels. Aberrant proliferation induced by abnormal cell cycle is a hallmark of cancer. Over the past few decades, several drugs that inhibit CDK activity have been created to stop the development of cancer cells. The third generation of selective CDK4/6 inhibition has proceeded into clinical trials for a range of cancers and is quickly becoming...

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PMID: 37240281
DOI: 10.3390/ijms24108939

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