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Article

Prognostic role of PIK3CA and TP53 in human papillomavirus-negative oropharyngeal cancers.

Tumori - 1 Jun 2018

Resteghini Carlo, Perrone Federica, Miceli Rosalba, Bergamini Cristiana, Alfieri Salvatore, Orlandi Ester, Guzzo Marco, Granata Roberta, Galbiati Donata, Cavalieri Stefano, Locati Laura, Licitra Lisa, Bossi Paolo

Abstract excerpt

BACKGROUND: Human papilloma virus (HPV)-negative oropharyngeal squamous cell carcinomas (OPCs) have a poorer prognosis and best management is an unmet need. We studied the prognostic role of epidermal growth factor receptor (EGFR) and PIK3CA amplifications and TP53 functional status. METHODS: Between 1992 and 2000, 90 consecutive patients with OPCs were treated with surgery, followed by radiotherapy in case of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29714670
DOI: 10.1177/0300891618765558

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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