Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Copy number amplification of the PIK3CA gene is associated with poor prognosis in non-lymph node metastatic head and neck squamous cell carcinoma.

BMC cancer - 20 Sept 2012

Suda Toshihito, Hama Takanori, Kondo Shu, Yuza Yuki, Yoshikawa Mamoru, Urashima Mitsuyoshi, Kato Takakuni, Moriyama Hiroshi

Abstract excerpt

BACKGROUND: Deregulation of the EGFR signaling pathway is one of the most frequently observed genetic abnormalities that drives cancer development. Although mutations in the downstream components of the EGFR signaling pathway, including KRAS, BRAF and PIK3CA, have been reported in numerous cancers, extensive mutation and copy number analysis of these genes in clinical samples has not been performed for head and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Class I Phosphatidylinositol 3-Kinases
Share to Comparative Genomic Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Head and Neck Neoplasms

Share to Lymphatic Metastasis

Share to Phosphatidylinositol 3-Kinases

Share to Proportional Hazards Models

Share to Squamous Cell Carcinoma of Head and Neck

Source

Open in PubMed Open full text

Identifiers

PMID: 22994622
DOI: 10.1186/1471-2407-12-416
PMCID: PMC3518180

Genes

BRAF
KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Copy number amplification of the PIK3CA gene is associated with poor prognosis in non-lymph node metastatic head and neck squamous cell carcinoma.PMID 22994622Read ↗

PIK3CA amplification is associated with poor prognosis among patients with curatively resected esophageal squamous cell carcinoma.Semantic proximity Read ↗

Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.Semantic proximity Read ↗

Novel mutations of PIK3CA gene in head and neck squamous cell carcinoma.Semantic proximity Read ↗

PIK3CA mutations and copy number gains in human lung cancers.Semantic proximity Read ↗

Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers.Semantic proximity Read ↗

Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Somatic mutation and gain of copy number of PIK3CA in human breast cancer.Semantic proximity Read ↗

Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinomaSemantic proximity Read ↗

Prognostic implications of PIK3CA amplification in curatively resected liposarcoma.Semantic proximity Read ↗

<i>PIK3CA</i> Mutations in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Genome-wide analysis of recurrent copy-number alterations and copy-neutral loss of heterozygosity in head and neck squamous cell carcinoma.Semantic proximity Read ↗

High frequency of activating PIK3CA mutations in human papillomavirus-positive oropharyngeal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.