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Article

Functional consequences of genetic variation in sodium channel modifiers in early onset lone atrial fibrillation.

Personalized medicine - 1 Mar 2018

Denti Federico, Paludan-Müller Christian, Olesen Søren-Peter, Haunsø Stig, Svendsen Jesper Hastrup, Olesen Morten Salling, Bentzen Bo Hjorth, Schmitt Nicole

Abstract excerpt

AIM: We investigated the effect of variants in genes encoding sodium channel modifiers SNTA1 and GPD1L found in early onset atrial fibrillation (AF) patients. PATIENTS & METHODS: Genetic screening in patients with early onset lone AF revealed three variants in GPD1L and SNTA1 in three AF patients. Functional analysis was performed by patch-clamp electrophysiology. RESULTS: Co-expression of GPD1L or its p.A326E...

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Source

Identifiers

PMID: 29714131
DOI: 10.2217/pme-2017-0076

Genes

SNTA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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