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Article

Proteomic and phenotypic characteristics of memory-like natural killer cells for cancer immunotherapy.

Journal for immunotherapy of cancer - 20 Jul 2024

Arellano-Ballestero Helena, Zubiak Agnieszka, Dally Chris, Orchard Kim, Alrubayyi Aljawharah, Charalambous Xenia, Michael Melina, Torrance Robert, Eales Trinity, Das Kushal, Tran Maxine G B, Sabry May, Peppa Dimitra, Lowdell Mark W

Abstract excerpt

BACKGROUND: Human and mouse natural killer (NK) cells have been shown to develop memory-like function after short-term exposure to the cocktail of IL-12/15/18 or to overnight co-culture with some tumor cell lines. The resulting cells retain enhanced lytic ability for up to 7 days as well as after cryopreservation, and memory-like NK cells (mlNK) have been shown to induce complete remissions in patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39032940
DOI: 10.1136/jitc-2023-008717
PMCID: PMC11261707

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