Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KIR downregulation by IL‐12/15/18 unleashes human NK cells from KIR/HLA‐I inhibition and enhances killing of tumor cells

6 Nov 2017

Abstract excerpt

To exploit autologous NK cells for cancer immunotherapy, it is highly relevant to circumvent killer cell immunoglobulin-like receptor (KIR)-mediated self-inhibition of human NK cells by HLA-I-expressing tumor cells. Here, we show that stimulation of NK cells with IL-12/15/18 for two days led to downregulation of surface expression of the inhibitory KIR2DL2/L3, KIR2DL1 and KIR3DL1 receptors on peripheral blood NK...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29105756
DOI: 10.1002/eji.201747128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KIR downregulation by IL‐12/15/18 unleashes human NK cells from KIR/HLA‐I inhibition and enhances killing of tumor cellsPMID 29105756Read ↗

High-Risk Leukemia: Past, Present, and Future Role of NK CellsSemantic proximity Read ↗

Natural Born Killers: NK Cells in Cancer TherapySemantic proximity Read ↗

Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical ExploitationSemantic proximity Read ↗

Human NK receptors: From the molecules to the therapy of high risk leukemiasSemantic proximity Read ↗

IL-12 regulates the expansion, phenotype, and function of murine NK cells activated by IL-15 and IL-18.Semantic proximity Read ↗

Implication of Interleukin-12/15/18 and Ruxolitinib in the Phenotype, Proliferation, and Polyfunctionality of Human Cytokine-Preactivated Natural Killer Cells.Semantic proximity Read ↗

Engineering CAR-NK cells to secrete IL15 sustains their anti-AML functionality, but is associated with systemic toxicitiesSemantic proximity Read ↗

Single-cell analysis of the human NK cell response to missing self and its inhibition by HLA class I.Semantic proximity Read ↗

Killer cell immunoglobulin-like receptor 3DL1 licenses CD16-mediated effector functions of natural killer cells.Semantic proximity Read ↗

IL-1R8 silencing improves the anti-tumor function of freshly isolated human NK cellsSemantic proximity Read ↗

Adoptively transferred natural killer cells maintain long-term antitumor activity by epigenetic imprinting and CD4 <sup>+</sup> T cell helpSemantic proximity Read ↗

A Novel Feeder cell based on 4-1BBL and Membrane-bound IL-21/ IL-15 Induce Highly Expansion and Anti-tumor Effect of Natural Killer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.