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Article

Adoptively transferred natural killer cells maintain long-term antitumor activity by epigenetic imprinting and CD4 <sup>+</sup> T cell help

5 Aug 2016

Abstract excerpt

Natural killer (NK) cell infusions can induce remissions in subsets of patients with different types of cancer. The optimal strategies for NK cell activation prior to infusion are still under debate. There is recent evidence that NK cells can acquire long-term functional competence by preactivation with the cytokines IL-12/15/18. The mechanisms supporting the maintenance of long-term NK cell antitumor activity...

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PMID: 27757318
DOI: 10.1080/2162402x.2016.1219009

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