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Article

Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy.

Molecular and cellular biology - 15 Jul 2018

Brody Matthew J, Vanhoutte Davy, Schips Tobias G, Boyer Justin G, Bakshi Chinmay V, Sargent Michelle A, York Allen J, Molkentin Jeffery D

Abstract excerpt

Thrombospondins are stress-inducible secreted glycoproteins with critical functions in tissue injury and healing. Thrombospondin-4 (Thbs4) is protective in cardiac and skeletal muscle, where it activates an adaptive endoplasmic reticulum (ER) stress response, induces expansion of the ER, and enhances sarcolemmal stability. However, it is unclear if Thbs4 has these protective functions from within the cell, from...

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Identifiers

PMID: 29712757
DOI: 10.1128/MCB.00114-18
PMCID: PMC6024163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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